Invasive fungal infection after liver transplantation
Conditions
Interventions
The control group:Treated with Caspofungin
The experimental group:Treated with Caspofungin and posaconazole
Sponsors
The Third Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Adult liver transplantation recipients in the Liver Transplantation Center of the Third Affiliated Hospital of Sun Yat-sen University with at least one of the following major or two minor risk factors: 1. Main risk factors: (1) Retransplantation of the liver; (2) Fulminant liver failure was diagnosed; (3) MELD-NA score >= 30; (4) Renal failure, requiring renal replacement therapy; (5) Preoperative ICU admission >= 48 hours; 2. Secondary risk factors: (1) MELD-NA score 20-30; (2) Split or living donor liver transplantation; (3) Roux-EN-Y choledochostomy; (4) Massive intraoperative blood transfusion (>= 20U, CRBC); (5) Acute kidney injury had not been treated with renal replacement therapy, and GFR < 50mL /min; (6) Preoperative candida colonization; (7) Early postoperative technical complications of Clavein GRADE III or above.
Exclusion criteria
Exclusion criteria: 1. Have received any systemic antifungal therapy in the past 2 weeks; 2. Have diagnosed or suspected fungal infection; 3. Allergic to echinocandins or azoles; 4. Expected to survive less than 7 days at the time of enrollment; 5. Unable to take oral medication for active upper gastrointestinal bleeding and perforation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of fungal infection;Infection marker; | — |
Countries
China
Contacts
Public ContactYi Shuhong
The Third Affiliated Hospital of Sun Yat-sen University
Outcome results
None listed