Heart failure
Conditions
Interventions
The experimental group:AV node ablation + left bundle branch pacing
The control group:Conventional drug treatment group
Sponsors
Jiangsu Province Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Unsuitable or rejected for AF catheter ablation and failure in rhythm control; 2. After 3 months of optimal drug treatment according to the guidelines (controlling resting heart rate <= 110bpm), the patient still had persistent AF combined with HF (LVEF < 50%); 3. Narrow QRS wave on ECG ( <= 120ms); 4. The patient is older than 18 years and has a life expectancy of more than 1 year; 5. Agree to participate in the clinical trial and sign a written informed consent.
Exclusion criteria
Exclusion criteria: 1. A history of acute coronary syndrome, cerebrovascular accident and gastrointestinal bleeding within the last 3 months; 2. Other serious heart disease requiring surgical treatment; 3. Any contraindications to ventricular rhythm resetting therapy; 4. Pregnant or preparing to become pregnant or mentally ill.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| All-cause mortality and HF readmission; | — |
Secondary
| Measure | Time frame |
|---|---|
| left ventricular ejection fraction;NT-proBNP; | — |
Countries
China
Contacts
Public ContactShan Qijun
Jiangsu Province Hospital
Outcome results
None listed