Autologous Peripheral Blood Mesenchymal Stem Cell Transplantation for Repair of Degree IV Local Cartilage Injury of Knee Joint

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100047618

Enrollment

Unknown

Registered

2021-06-20

Start date

2021-08-01

Completion date

Unknown

Last updated

2022-02-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee cartilage injury

Interventions

Experimental group:Autologous peripheral blood mesenchymal stem cell therapy

Control group 1 :Microfracture

Control group 2:Microfracture + collagen membrane

Control group 3:Autologous osteochondral transplantation

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. Adults over the age of 18 and under the age of 60, regardless of gender. 2. Symptoms, signs and imaging changes are in line with localized ? degree cartilage defect of knee joint or chondromalacia patella, patellofemoral joint cartilage injury, mild to moderate knee osteoarthritis. 3. Other treatment methods are ineffective. 4. No other knee cartilage defect treatments will be performed during the trial period. 5. Subjects must be able to communicate well with investigators and comply with the requirements of the research, and must give written, signed and dated informed consent before any research-related activities. All relevant legal representatives will also sign written research consents in accordance with local laws and regulations.

Exclusion criteria

Exclusion criteria: 1. Subjects with cartilage defect diameter = 160mmHg and/or diastolic blood pressure >= 95mmHg), congestive heart failure (New York Heart Association status class III or IV). 12. Subjects with serum creatinine levels exceeding 2.0 mg/dl (176.8 µmol/L). 13. Total white blood cell (WBC) count at screening <2500/µL, or platelets <100000/µL or neutrophils <1500/µL or hemoglobin <8.5 g/dL. 14. Pregnant or lactating women, pregnancy is defined as the state of a woman after conception until termination of pregnancy, confirmed by a positive hCG laboratory test result. 15. Females of childbearing potential, defined as all females who are biologically capable of becoming pregnant unless they use an effective method of contraception throughout the duration of study treatment administration. 16. History of alcohol or drug abuse or evidence of ongoing abuse within six months prior to baseline.

Design outcomes

Primary

Measure	Time frame
MOCART score;	—

Secondary

Measure	Time frame
WOMAC score;VAS score;IKDC score;	—

Countries

China

Contacts

Public ContactYu Jiakuo

yujiakuo@126.com+86 13331031448

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026