None listed
Conditions
Interventions
Group A:Continuous infusion of low-dose oxycodone hydrochloride 0.5 mg per hour + dexmedetomidine 0.3 µg/kg per hour
Group B:Continuous infusion of medium-dose oxycodone hydrochloride 0.75 mg per hour + dexmedetomidine 0.3 µg/kg per hour
Group C:Continuous infusion with high-dose oxycodone hydrochloride 1 mg per hour + dexmedetomidine 0.3 µg/kg per hour
Sponsors
West China Second University Hospital, Sichuan University
Eligibility
Sex/Gender
Female
Age
20 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria for preeclampsia of the 8th edition of Obstetrics and Gynecology, 32-42 weeks of gestation, singleton pregnancy; aged 20-45 years, body mass index (BMI) 18.5-30 kg/m^2. 2. Preoperative blood pressure can be controlled within 120-160/80-100 mmHg, and heart rate is 60-120/min. 3. Elective cesarean section under combined spinal-epidural anesthesia, the operation time is less than 2 hours, and the intraoperative blood loss is less than 1000 ml. 4. Under anesthesia, take the left lateral position, puncture in the L3-4 space, inject 2.5 ml of 0.5% bupivacaine intrathecally, after 5 minutes, if the anesthesia level did not reach T6, 3 ml of 2% lidocaine was injected epidurally, and the body position was adjusted so that the anesthesia level was not higher than T6. After the fetus was removed, intravenous midazolam 2 mg + sufentanil 5 ug was administered. The highest point of the anesthesia plane measured at the end of the operation was not higher than T6 and not lower than T10.
Exclusion criteria
Exclusion criteria: 1. Those allergic to dexmedetomidine and oxycodone; 2. Severe sinus bradycardia and atrioventricular block; 3. Chronic obstructive respiratory disease, severe heart disease, preoperative pulse oxygen saturation < 92%; 4. Patients with paralytic ileus and acute abdomen; 5. Those taking monoamine oxidase inhibitors or within 2 weeks after discontinuation; 6. Moderate to severe liver and kidney dysfunction; 7. Other analgesic and sedative drugs were added to the anesthesia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Digital pain scale;LOS sedation score;Mean arterial pressure before and after pressing the fundus at different time points;Changes in heart rate during rest and fundus compression at different time points; | — |
Secondary
| Measure | Time frame |
|---|---|
| Depressive state; | — |
Countries
China
Contacts
Public ContactShu Lijuan
West China Second University Hospital, Sichuan University
Outcome results
None listed