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Clinical efficacy of Hand-foot-yan Ning gel in the treatment of hand foot syndrome caused by multitarget tyrosine kinase inhibitors

Clinical efficacy of Hand-foot-yan Ning gel in the treatment of hand foot syndrome caused by multitarget tyrosine kinase inhibitors

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100047578
Enrollment
Unknown
Registered
2021-06-20
Start date
2021-06-21
Completion date
Unknown
Last updated
2022-02-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hand foot syndrome

Interventions

Experimental group:External application of Hand-foot-yan Ning gel

Sponsors

Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Patients with malignant tumors confirmed by pathology or cytology; 2. Patients with grade 1 or above hand-foot syndrome after receiving multi-target tyrosine kinase inhibitor therapy; 3. Komofsky score > 60 points; 4. No serious heart, liver, kidney and other important organ dysfunction; 5. The expected survival period is more than 3 months; 6. Aged 18 to 80 years; 7. Good compliance; 8. Voluntarily participate and sign the informed consent.

Exclusion criteria

Exclusion criteria: 1. Those with preexisting nervous system diseases; 2. Diabetes complicated with nervous system diseases; 3. Patients who are receiving other non-chemotherapy drugs that may cause neurotoxicity; 4. Uncontrolled infections and metabolic diseases; 5. Pregnant women or mentally ill patients.

Design outcomes

Primary

MeasureTime frame
Overall efficiency of HFS improvement;

Secondary

MeasureTime frame
Improvement score of common symptoms of tumor;Improvement of quality of life score;

Countries

China

Contacts

Public ContactChen Gang

Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology

dragonchengang@sina.com+86 13871560923

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026