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Early enteral nutrition protects mitochondrial function through AMPK signal network and promotes the clinical and mechanism research of intestinal barrier repair

Early enteral nutrition protects mitochondrial function through AMPK signal network and promotes the clinical and mechanism research of intestinal barrier repair

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100047566
Enrollment
Unknown
Registered
2021-06-20
Start date
2021-07-01
Completion date
Unknown
Last updated
2022-02-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gastrointestinal tumor

Interventions

Group 1:early enteral nutrition
Group 2:parenteral nutrition

Sponsors

Renmin Hospital of Wuhan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 90 Years

Inclusion criteria

Inclusion criteria: 1. Aged 18 to 90 years; 2. Ability to communicate effectively; 3. Conscious; 4. Informed consent to join this study; 5. Stay overnight in hospital; 6. Stomach surgery: laparoscopic distal gastrectomy; laparoscopic total gastrectomy; open distal gastrectomy; open total gastrectomy; palliative surgery for gastric cancer (including gastrointestinal bypass surgery, jejunostomy, gastrostomy, etc.); subtotal gastrectomy for other benign and malignant gastric diseases; 7. Colorectal surgery: laparoscopic radical colon cancer surgery; laparoscopic radical rectal cancer surgery; open radical colon cancer surgery; open radical rectal cancer surgery; colorectal palliative surgery (including enterostomy, colon bypass surgery, etc.); enterectomy and anastomosis for other colorectal diseases; 8. Duodenum, pancreas, and lower bile duct operations: laparoscopic pancreaticoduodenectomy; open pancreaticoduodenectomy; laparoscopic pancreatic body and tail resection; open pancreatic body and tail resection; other palliative surgeries (such as gastrointestinal anastomosis, cholangioenterostomy, etc.).

Exclusion criteria

Exclusion criteria: None

Design outcomes

Primary

MeasureTime frame
mitochondrial DNA;

Secondary

MeasureTime frame
enteric fatty acid binding protein;citrulline;

Countries

China

Contacts

Public ContactFu Tao
tfu001@whu.edu.cn+86 13720120190

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026