bronchopulmonary dysplasia
Conditions
Interventions
Intervention group:Surface active materialf+Budesonide
Control group:Surface active material+ saline
Sponsors
BaYi Children's Hospital, Seventh Medical Center of Chinese PLA General Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Preterm infants with birth weight between 500-1499 g; 2.Severe respiratory distress at birth and require resuscitation or failure to response to NCPAP or to high nasal flow therapy within 4 hours after birth. Failure to NCPAP will be defined as any one of the followings: (1)Requirement of FIO2>0.3; (2)PCO2>=60 mmHg; (3) Three depressions of severe inspiration; (4)apnea. These infants are justified to receive surfactant therapy by current medical standard.
Exclusion criteria
Exclusion criteria: 1.Severe congenital abnormalities; 2.Lethal cardiopulmonary status at birth.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| chest radiography;blood routine examination;arterial blood gas analysis; | — |
Secondary
| Measure | Time frame |
|---|---|
| serum glucose;electrolytes;urea nitrogen;blood pressure; | — |
Countries
China
Contacts
Public ContactFeng Zhichun
BaYi Children's Hospital, Seventh Medical Center of Chinese PLA General Hospital
Outcome results
None listed