hypotension in women with severe eclampsia undergoing caesarean section
Conditions
Interventions
phenylephrine group:use phenylephrine when hypotension happens
norepinephrine group:use norepinephrine when hypotension happens
Sponsors
Women's Hospital, School of Medicine, Zhengjiang University
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1.Aged 18 to 40 years; 2.ASA class II or III; 3.Singleton pregnancy patients with severe eclampsia. Severe eclampsia was defined as systolic blood pressure >=160mmHg and/or diastolic blood pressure >=110mmHg (bed rest, at least 4 hours between blood pressure measurements); Or (1) thrombocytopenia (platelets <100x10^9 / L); (2)Liver function damage (serum transaminase level is more than 2 times the normal value); (3)Renal impairment (serum creatinine increased more than 1.1mg/dL or more than 2 times the normal value); 4.New onset cerebral or visual disturbances.
Exclusion criteria
Exclusion criteria: 1.Any contraindication to spinal anesthesia; 2.Active labor; 3.Placenta previa or other placenta abnormalities; 4.Multiple pregnancy; 5.Pulmonary edema; 6.Allergy to phenylephrine and norepinephrine; 7.Umbilical cord prolapse; 8.kKnown fetal abnormalities; 9.Less than 28 weeks gestation; 10.Refuse to sign informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| umbilical artery PH value; | — |
Secondary
| Measure | Time frame |
|---|---|
| umbilical vein PH value;heart stroke;maternal outcomes (nausea and vomiting; bradycardia; tachycardia; hypertension; dizzy; dyspnea);Other non-invasive hemodynamic parameters except cardiac displacement;stroke volume;systemic vascular resistance; | — |
Countries
China
Contacts
Public ContactQian Xiaowei
Women's Hospital, School of Medicine, Zhengjiang University
Outcome results
None listed