Cancer
Conditions
Interventions
intervention group:transcutaneous vagaus nerve stimulation
sham intervention group:transcutaneous vagaus nerve stimulation at the tragus without current
Sponsors
The First Affiliated Hospital of the Air Force Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Aged 18 to 65 years; 2.Participants diagnosed with nasopharyngeal cancer, esophageal cancer,lung cancer, or cervical cancer, suitable for radical radiotherapy or chemotherapy; 3.Participants diagnosed with rectal cancer, suitable for neoadjuvant radiotherapy or chemotherapy before surgery; 4.Participants diagnosed with breast cancer, suitable for adjuvant radiotherapy after surgery; 5.Eastern Cooperative Oncology Group (ECOG) physical condition score: 0~1 point.
Exclusion criteria
Exclusion criteria: 1.Participants with organic brain lesions (cerebral hemorrhage, large-area cerebral infarction, encephalitis, epilepsy, etc.); 2.Participants with peptic ulcer, arrhythmia, or cardiac corrected QT interval> 450ms; 3.Participants who have slow breathing (less than 10 breaths per minute); 4.Participants who are or have been diagnosed with other major diseases (coronary heart disease, pulmonary heart disease, etc.); 5.Participants who are currently or have been diagnosed with mental disorders other than major depressive disorder; 6.Participants who are or have participated in vagus nerve or transcranial electrical stimulation treatment for less than 3 months; 7.Participants who are not suitable for vagus nerve stimulation treatment; 8.Participants who refuse to sign informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| patient's overall fatigue score; | — |
Secondary
| Measure | Time frame |
|---|---|
| the difference between the patient's overall fatigue score and baseline score;quality of life scale;the depression and anxiety level of participants;hot flashes score;absolute value, proportion and reduction rate of lymphocytes and their subsets compared with baseline;Levels of c-type reactive protein, tumor necrosis factor -a, interleukin-6 and other inflammatory factors;the level of sleep quality; | — |
Countries
China
Contacts
Public ContactZhao Li'na
The First Affiliated Hospital of the Air Force Medical University (Xijing Hospital)
Outcome results
None listed