Major depressive disorder(MDD)
Conditions
Interventions
Test group:Selective Serotonin Reuptake Inhibitor (SSRI)
Sponsors
Beijing Anding Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Out-patients, male or female, aged 18 to 65 years; 2. Meet the diagnosis standard of DSM-IV/MINI, first episode or recurrence, current episode depressed without psychotic features; 3. Did not under anti depressive treatment or cumulative treatment no more than 7 days; 4. Having 17-item Hamilton Depression Rating Scale (HAMD-17) total score = 14; 5. Primary school or above education background, to be able to understand the content of the questionaire; 6. No contraindications for MRI; 7. Signed informed consent.
Exclusion criteria
Exclusion criteria: 1. A history of mania or hypomania; 2. Any preexisting or concurrent co-morbid primary diagnoses that met the DSM-IV criteria for any Axis I disorder other than MDD, such as schizophrenia or bipolar disorders; 3. Have alcohol/drug dependence or acute poisoning; 4. Pregnant or lactating women; 5. Currently have a serious risk of suicide judged by investigators, suicide item of HAMD-17 score = 3; 6. Currently have severe physical illnesses which researchers think it is risky and not eligible to participate; 7. Unable to tolerate or failed to SSRI.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Remission rate; | — |
Primary
| Measure | Time frame |
|---|---|
| The change of HAMD-17 total score;Difference of neuroimaging feature; | — |
Countries
China
Contacts
Public ContactLiu Rui
Beijing Anding Hospital, Capital Medical University
Outcome results
None listed