Anterior circulation large vessel occlusion
Conditions
Interventions
Group A:Endovascular thrombectomy
Group B:Standard medical therapy
Sponsors
Zhongshan Hospital of Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: Clinical inclusion criteria 1. Signs and symptoms consistent with the diagnosis of an acute anterior circulation ischemic stroke; 2. Aged 18 to 85 years old; 3. Baseline NIHSS >= 6; 4. Mechanical thrombectomy can be initiated (femoral puncture) within 6–24 h of stroke onset. Stroke onset is defined as the time of the last known normal; 5. Pre-stroke mRS =15 mL).
Exclusion criteria
Exclusion criteria: Clinical exclusion criteria 1. Serious heart/renal/liver dysfunction; 2. Pregnancy; 3. Known allergy to iodine; 4. Known hereditary or acquired hemorrhagic diathesis, coagulation factor deficiency, and recent oral anticoagulant therapy with INR > 3'; 5. Baseline platelet count 22.2 mmol/L; 7. Severe sustained hypertension (systolic blood pressure >185 mmHg or diastolic blood pressure > 110 mmHg); 8. Treated with tPA at > 4.5 h after time last known well; 9. Treated with tPA at 3–4.5 h after last known well and any of the following: aged > 80 years, current anticoagulant use, history of diabetes and prior stroke, NIHSS score >25; 10. Anticipated life expectancy 10 mm), arteriovenous malformation, moyamoya disease, or intracranial tumor (except asymptomatic meningioma); 3. Significant mass effect with midline shift as confirmed on CT or MRI; 4. Occlusion in multiple vascular territories (bilateral anterior circulation or anterior circulation/vertebrobasilar system) as confirmed on CTA or MRA; 5. Intracranial stents are implanted in the same vascular territory that precludes the safe deployment or removal of the thrombectomy device.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| NIH Stroke Scale, NIHSS;Barthel; | — |
Primary
| Measure | Time frame |
|---|---|
| mRS; | — |
Countries
China
Contacts
Public ContactWang Xin
Zhongshan Hospital of Fudan University
Outcome results
None listed