Experimental study of miR-146b-5p on the regulation of sepsis immunity by NF-?B/GSDMD pathway

Status

Recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2100047480

Enrollment

Unknown

Registered

2021-06-20

Start date

2021-08-01

Completion date

Unknown

Last updated

2022-02-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sepsis

Interventions

healthy control group:Nil

group of ICU patients without infection:Nil

Sepsis group:Nil

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1.Aged >18 years; 2.Sepsis 3.0 defined diagnostic criteria: positive or suspected infection, and Sequential Organ Failure Score (SOFA) >=2 caused by infection.

Exclusion criteria

Exclusion criteria: 1. There are malignant tumors, autoimmune diseases, hematopoietic diseases and immunodeficiency diseases; 2. Those who have used radiotherapy, chemotherapy and immunosuppressive agents within six months; 3. Discharged or died in the middle of the experiment.

Design outcomes

Primary

Measure	Time frame
miR-146b-5p expression;Lymphocyte subpopulation analysis;Apoptosis;pyroptosis;	—

Countries

China

Contacts

Public ContactLong Xianli

The Second Affiliated Hospital of Chongqing Medical University

514815469@qq.com+86 13896519046

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026