cancer-related fatigue
Conditions
Interventions
Control group:placebo
Sponsors
The First Affiliated Hospital of Guangzhou University of Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients with non-small cell lung cancer diagnosed by pathology or cytology; 2. Meet the diagnostic criteria for cancer-related fatigue; 3. The estimated survival time is more than 3 months, PS<=2, aged 18 to 80 years; 4. Patients who are not suitable for targeted drug therapy; 5. According to the guidelines, patients need to receive platinum-containing dual-drug-based chemotherapy, including AP (pemetrexed + cisplatin/carboplatin), TP (paclitaxel + cisplatin/carboplatin), DP (docetaxel) + Cisplatin/carboplatin), GP (gemcitabine + cisplatin/carboplatin); can be combined with anti-vascular drugs and immune checkpoint inhibitors; 6. Those who voluntarily accept the treatment of this program, can adhere to the follow-up visit as prescribed by the doctor and have good compliance.
Exclusion criteria
Exclusion criteria: 1. Any situation that may hinder the subject from completing the clinical trial process, including but not limited to serious, difficult to control organic disease or infection, unstable angina, congestive heart failure, etc.; hypothyroidism has not been controlled; 2. Severe liver and kidney dysfunction (serum creatinine >= 1.5 ULN; ALT or AST >= 5 ULN; bilirubin >= 1.5 ULN); 3. Patients with neurological or mental disorders who are symptomatic and difficult to control, and others who cannot complete the questionnaire independently or assist by others.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Brief fatigue inventory;Gut Microbiota; | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of life;Clinical symptom score;Immune Function;Neuroendocrine function;Mental Sleepy score and Mental Fatigue score; | — |
Countries
China
Contacts
Public ContactCao Yang
The First Affiliated Hospital of Guangzhou University of Chinese Medicine
Outcome results
None listed