Cerebral microvascular disease complicated with cognitive dysfunction
Conditions
Interventions
Sponsors
The Second People's Hospital of Lianyungang
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Magnetic resonance imaging (MRI) scan showed lacunar infarction (LI), lacune (LACune), white matter lesion (WML), perivascular space enlargement and cerebral microhemorrhage (CMB), etc., which met the clinical diagnosis requirements of the 2014 edition of Expert Consensus on diagnosis and Treatment of Cerebral microvascular Disease.
Exclusion criteria
Exclusion criteria: 1.Obvious blindness, deafness and difficulty in speech expression; 2.Diagnose schizophrenia, affective disorder, organic mental disorder and mental retardation; 3.Dementia syndromes in degenerative diseases (Parkinson's disease, diffuse Lewy body disease, chronic progressive chorea, progressive suprarenal palsy, thalamic dementia, Creutzfeldt-Jakob disease); 4.The presence of pseudodementia (depression, delirium, brain abscess, brain tumor, hypothyroidism, hypophysis, vitamin deficiency, chronic renal failure and hepatic encephalopathy and etc.); 5.Patients have normal cognitive function but have taken cholinesterase inhibitors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Apolipoprotein E gene expression;Neurofilament protein AD7c-NTP levels; | — |
Countries
China
Contacts
Public ContactShen Xiaozhu
The Second People's Hospital of Lianyungang
Outcome results
None listed