acute lung injury and acute respiratory distress syndrome
Conditions
Interventions
Experimental group:Lobelin
Control group:conventional therapy
Sponsors
The Third Affiliated Hospital of Sun Yat-Sen University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Male or female aged 18 to 65 years; 2. The diagnosis meets the Berlin diagnostic criteria for ARDS; 3. ARDS was diagnosed within 1 week; 4. Capable of understanding the purpose and risk of the study; 5. Patients or proxy must give written informed consent before any assessment is performed.
Exclusion criteria
Exclusion criteria: 1. ARDS was diagnosed 1 week later; 2. Pregnancy, lactation or perinatal period; 3. malignant tumor; 4. Severe liver failure, MELD score>30; 5. Predicted mortality risk of patients within 24h>80%; 6. Severe end-stage lung disease; 7. ECMO patients are undergoing implementation; 8. HIV seropositive or HTLV seropositive; 9. Any clinical-relevant condition that might affect study participation and/or study results; 10. Participation in any other intervention trial; 11. Unwillingness or inability to following the study protocol in the investigators opinion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ventilation-free days; | — |
Secondary
| Measure | Time frame |
|---|---|
| Rates of drug-related adverse events;Oxygenation index;Vital signs;Lung injury score;Inflammation levels;SOFA score; | — |
Countries
China
Contacts
Public ContactYi Huimin
The Third Affiliated Hospital of Sun Yat-Sen University
Outcome results
None listed