Early Identification and Blood Pressure Mangement in Acute Ischemic Stroke with Anterior Circulation Large Artery Occlusion

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100047390

Enrollment

Unknown

Registered

2021-06-13

Start date

2020-12-01

Completion date

Unknown

Last updated

2022-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ischemic stroke

Interventions

Antihypertensive treatment group:Reduce systolic blood pressure by 20±5mmHg

Standard treatment group:Standard treatment

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Part A (1) Age>18 years old. (2) Patients with ischemic stroke within 24 hours of onset. (3) Complete head CTA or MRA or DSA examination within 24 hours. (4) With detailed NIHSS score. 2. Part B (1) Meet the selection criteria in Part A. (2) CTA or MRA or DSA is confirmed as anterior circulation large artery occlusion. (3) Systolic blood pressure >=150mmHg at admission. (4) The patient or his family members signed an informed consent form. Anterior circulation LAO includes: anterior circulation large artery occlusion including: internal carotid artery intracranial or extracranial segment, middle cerebral artery (M1, M2 segment), anterior cerebral artery (A1 segment) occlusion.

Exclusion criteria

Exclusion criteria: 1. Part A (1) Patients with cerebral hemorrhage or subarachnoid?hemorrhage. (2) Patients who are unsuitable or difficult to complete cranial CTA or MRA or DSA (such as pregnant women, contrast agent allergy, severe renal insufficiency, unstable vital signs, etc.). (3) Patients with previous anterior circulation arterial occlusion or severe stenosis. 2. Part B (1) Meet the exclusion criteria of Part A. (2) Patients with acute myocardial infarction, unstable angina, aortic dissection or severe cardiopulmonary failure. (3) Patients with intracranial aneurysms, arteriovenous fistulas and other cerebrovascular structural malformations. (4) There are contraindications for antihypertensive therapy (such as severe stenosis of multiple intracranial arteries, renal failure, etc.). (5) Patients with other serious systemic diseases. (6) Patients with endovascular therapy within 24 hours of onset. (7) Other situations that are not suitable for entry into the group.

Design outcomes

Primary

Measure	Time frame
Vascular imaging;clinical out come at 90 days;	—

Secondary

Measure	Time frame
Admission NIHSS score;core infarct volume;neurological function at 7 days;	—

Countries

China

Contacts

Public ContactWu Jian

Beijing Tsinghua Changgung Hospital

wujianxuanwu@126.com+86 13466766485

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026