prostatic cancer
Conditions
Interventions
experimental group:CalliSpheres loaded with drug-loaded microspheres and epirubicin
Sponsors
Meizhou People's Hospital
Eligibility
Sex/Gender
Male
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Prostate cancer is confirmed by puncture or electrotomy specimen; 2. IPSS score>7 points, QOL score>3 points, KPS score above 60 points; 3. Patients with hormone-sensitive prostate cancer who refuse surgery or endocrine therapy; 4. Patients with acute lower urinary tract obstruction and hematuria will be selected, those with obvious symptoms and no acute symptoms should be treated with hormone medication for at least 4 weeks, residual urine volume > 50mL, and radiotherapy should be stopped for at least 3 months to achieve CRPC; 5. Prostate volume>25mL; 6. Bone marrow hematopoietic function is not significantly impaired (white blood cells >= 3.5x10^9/L, platelets >=100x10^9/L, hemoglobin >= 90.0 g/L), liver and kidney functions are basically normal; 7. The conditions of bilateral iliac vessels can satisfy the operation; 8. The patient has good compliance, can cooperate with treatment and facilitate observation; 9. Sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Received other radiotherapy or chemotherapy three months before enrollment; 2. Physical function: KPS score less than 60 points; 3. Heart, liver, and kidney dysfunction (heart function grade III and above; AST and/or ALT > 4 times the upper limit of normal; creatinine > 2mg/L); 4. Patients with neurological dysfunction or cognitive impairment; 5. Patients with active infections; 6. TACE, epirubicin contraindications; 7. Patients with poor compliance such as floating population; 8. Participants in clinical trials of other experimental drugs or devices within four weeks.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| International prostate symptom score;Patient residual urine volume;Maximum urine flow; | — |
Countries
China
Contacts
Public ContactChen Nanhui
Meizhou People's Hospital
Outcome results
None listed