Influence of different general anesthesia methods on neurocognitive impairment in elderly patients during perioperative period

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100047359

Enrollment

Unknown

Registered

2021-06-12

Start date

2021-06-16

Completion date

Unknown

Last updated

2022-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neurocognitive dysfunction

Interventions

Group 1:Propofol

Group 2:Sevoflurane

Group 3:Propofol + Sevoflurane

Group 4:None

Eligibility

Sex/Gender

All

Age

60 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Aged 60-75 years, body mass index (BMI) 18-25 kg/m^2; 2. American Association of Anesthesiologists (ASA) Grade I-II; 3. Able to complete various cognitive function tests before surgery.

Exclusion criteria

Exclusion criteria: 1. Combined preoperative neuropsychiatric diseases including preoperative schizophrenia, epilepsy, history of Parkinson's disease or myasthenia gravis and other neurosurgical diseases; 2. Communication barriers before surgery due to coma, language barriers, serious illnesses, etc.; 3. Severe disease, severe liver dysfunction (Child-Pugh grade C), or severe renal dysfunction (preoperative dialysis); 4. Alcoholism and drug abuse; 5. Preoperative MMSE score < 24 points; 6. Diabetes.

Design outcomes

Primary

Measure	Time frame
Postoperative cognitive dysfunction;	—

Countries

China

Contacts

Public ContactTian Gang

tiangang771020@aliyun.com+86 13986913791

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026