Clinical, biochemical and microbiological effects of the adjunctive use of Er, Cr: YSGG laser in the treatment of type 2 diabetes mellitus with periodontitis: a randomized controlled clinical study

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100047307

Enrollment

Unknown

Registered

2021-06-12

Start date

2021-07-01

Completion date

Unknown

Last updated

2022-02-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontitis

Interventions

SRP group:scaling and root planning(SRP)

SRP plus Er, Cr: YSGG group:scaling and root planning(SRP) plus Erbium, Chromium: Yttrium-Scandium-Gallium- Garnet(Er, Cr: YSGG) laser

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Periodontitis: according to the diagnostic criteria recommended by Tonetti Maurizio et al. In 2017, it was diagnosed as stage II - IV periodontitis, there were no less than 16 remaining teeth (excluding the third molars), at least 4 teeth with periodontal pocket depth >= 5 mm, attachment loss >= 5 mm and BOP positive; 2. Diagnosed as type 2 diabetes: according to the diagnostic criteria of WHO diabetes in 1999, the course of disease should be at least one year, glycated hemoglobin A1c(GHbAlc) < 11%); 3. Stable disease; 4. Recently, there was no change in medication, diet and exercise habits.

Exclusion criteria

Exclusion criteria: 1. There was a history of antibiotics, non steroidal anti-inflammatory drugs or hormone drugs within 6 months; 2. There was a history of periodontal treatment or surgery within 6 months; 3. With serious diabetic cardiovascular complications or suffering from systemic diseases other than diabetes, such as cardiovascular diseases, rheumatoid diseases, endocarditis, nephrotic syndrome, malignant tumors, etc.; 4. Pregnant or lactating women; 5. The patients with poor general condition could not receive periodontal examination and / or treatment; 6. Smokers; 7. Those who can't return visit on schedule.

Design outcomes

Primary

Measure	Time frame
Probing depth;Clinical attachment loss;Gingival crevicular fluid;Tumor necrosis factor-a;Interleukin-6;Interleukin-1 ß;Aggregatibacter actinomycetemcomitans;Fusobacterium nucleatum;Porphyromonas gingivalis;Prevotella intermedia;Tannerella forsythia;Treponema denticola;HbA1c;	—

Secondary

Measure	Time frame
Bleeding on probe;Plaque index;Suppuration;Gingival bleeding index;Fasting blood glucose;	—

Countries

China

Contacts

Public ContactZhang Yanbiao

Weifang Medical University

zhangyb@wfmc.edu.cn+86 13256362257

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026