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The use of morning urinary gonadotropins and sexual hormones in the diagnosis and monitoring treatment of central precocious puberty

The use of morning urinary gonadotropins and sexual hormones in the diagnosis and monitoring treatment of central precocious puberty

Status
Recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2100047299
Enrollment
Unknown
Registered
2021-06-12
Start date
2020-12-01
Completion date
Unknown
Last updated
2022-02-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

precocious puberty

Interventions

Gold Standard:gonadotropin releasing hormone stimulation test
Index test:luteinizing&#32
hormone,&#32
follicle&#32
stimulating&#32
estradiol,&#32
prolactin,&#32
progesterone,&#32
testosterone,&#32
and&#32
human&#32
chorionic&#32
gonadotropin

Sponsors

The Children's Hospital, Zhejiang University School of Medicine
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
3 Years to 10 Years

Inclusion criteria

Inclusion criteria: Chinese girls with clinical signs of precocious puberty including progressive breast development accompanied by rapid growth (> 6-7 cm/year) and bone maturation were admitted.

Exclusion criteria

Exclusion criteria: Patients with an evidence of tumor, adrenal disease, gonadal disease hypothyroidism or central nervous system disorder were excluded from this study.

Design outcomes

Primary

MeasureTime frame
height;body weight;bone age;Tanner stage;luteinizing hormone;follicle stimulating hormone;estradiol;prolactin;progesterone;human chorionic gonadotropin;testosterone;SEN, SPE, ACC, AUC of ROC;—

Countries

China

Contacts

Public ContactJunfen Fu

The Children's Hospital, Zhejiang University School Of Medicine

fjf68@qq.com+86 13777457849

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026