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The protective effect and mechanism of ALOXs on hepatic ischemia-reperfusion injury by low central venous pressure

Low central venous pressure regulates the protective effect and mechanism of arachidonic acid-lipoxygenase on hepatic ischemia-reperfusion injury

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100047297
Enrollment
Unknown
Registered
2021-06-11
Start date
2020-06-01
Completion date
Unknown
Last updated
2022-02-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Liver cancer

Interventions

Experimental group:Low central venous pressure technology
Control group:normal CVP

Sponsors

Hu'nan Cancer Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. Aged 18 to 60 years; 2. Body mass index within the normal range (1+/-20%); 3. Preoperative diagnosis must meet the relevant standards in the 2011 version of the primary liver cancer diagnosis and treatment specifications, and postoperative pathology The result was hepatocellular carcinoma; 4. ASA I-II; 5. Before the trial, the patient or his legal representative understood and voluntarily signed an informed consent form approved by the ethics committee.

Exclusion criteria

Exclusion criteria: 1. Participated in other clinical trials within 4 weeks before the start of this study; 2. No hepatic portal block was required during the operation; 3. Severe liver and kidney insufficiency; 4. Cases of severe heart, brain and lung diseases and hypertension; 5. Tumor diameter > 10 cm; 6. Patients who are unwilling to participate in this study for any reason.

Design outcomes

Primary

MeasureTime frame
complication;

Secondary

MeasureTime frame
Arachidonic acid-lipoxygenase;

Countries

China

Contacts

Public ContactYang Jinfeng

Anesthesia Surgery Center of Hu'nan Cancer Hospital

315977705@qq.com+86 13875985950

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026