hemodynamic alteration in response to anesthesia induction
Conditions
Interventions
Control group:sufentanil 0.3µg/kg
Experimental group:nalbuphine 0.3mg/kg
Sponsors
The department of anesthesilogy, Zichang People's Hospital, Shaanxi, China
Eligibility
Sex/Gender
All
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: 1. Patients undergoing elective surgery under general anesthesia; 2. Aged 18 to 64 years; 3. BMI 18-29.5; 4. There is no restriction on gender; 5. ASA classification i-iii level; 6. The operation method is a small and medium-sized operation completed within 2 hours.
Exclusion criteria
Exclusion criteria: 1. Patients with diabetes, Cushing syndrome, pituitary tumor, adrenal tumor and other diseases; 2. Patients who use hormone drugs for a long time; 3. Asthma patients; 4. Within 2 weeks of taking monoamine oxidase inhibitor; 5. Patients with severe neurological or mental illness; 6. Chronic pain and long-term use of analgesics or psychotropic drugs (opioid analgesics, non-steroidal anti-inflammatory drugs, sedatives, antidepressants) history; 7. The heart, lung, liver, and kidney functions are severely abnormal; 8. Patients with severe hypertension or hypotension; 9. Patients with bradycardia or tachycardia; 10. Use sedatives, antiemetics and antipruritic drugs 24 hours before surgery; 11. Patients who are allergic to soybeans, milk, and drugs used during surgery; 12. Other factors that may interfere with the results of the experiment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Heart rate;Systolic blood pressure ;Diastolic blood pressure;Mean arterial pressure ; | — |
Secondary
| Measure | Time frame |
|---|---|
| The alterations in HR after intubation;The consumption of opioid drug;The hemodynamic change >=20%;The times and doses of vaszoactive agents;extubation time; | — |
Countries
China
Contacts
Public ContactXu Jun
The department of anesthesilogy, Zichang People's Hospital
Outcome results
None listed