The dose range of remazolam tosylate for induction and maintenance of general anesthesia in the elderly
Conditions
Interventions
Experimental group1:In the induction period of the remazolam tosylate group, the administration rate was 6 mg/kg/h
Experimental group2:In the induction period of the remazolam tosylate group, the rate of administration was 12 mg/kg/h
Experimental group3:The loading dose of propofol during the induction period is 2.0-2.5 mg/kg
Sponsors
Dongguan People's Hospital
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Subjects have a full understanding of the purpose and significance of this trial, volunteer to participate in this clinical trial, and sign an informed consent; 2. Patients who need general anesthesia for tracheal intubation for elective surgery; 3. Aged 60 to 80 years, Gender is not limited.
Exclusion criteria
Exclusion criteria: 1. Those who are allergic to remazolam tosylate, propofol, sufentanil and other pharmaceutical ingredients or components that may be used in the research; 2. Patients who have used narcotic analgesics, sedatives or non-steroidal anti-inflammatory drugs for a long time; 3. Opioid dependent or opioid tolerant; 4. Despite the use of vasoactive drugs, there are still patients with systemic hypotension; 5. Bradycardia, heart rate <55 beats/min; 6. High-level atrioventricular block without a pacemaker; 7. Combined with craniocerebral injury and intracranial hypertension; 8. Patients with severe heart, lung, liver, and kidney function abnormalities; 9. Those with a history of allergic diseases; 10. Those who have a history of mental illness; 11. Those with fat metabolism disorders; 12. Foreseeable difficult intubation; 13. The investigator judges that the subject is not suitable for other conditions in the clinical trial; patients with myasthenia gravis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Anesthesia and sedation success rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Anesthesia induction time;Anesthesia recovery time; | — |
Countries
China
Contacts
Public ContactXie Haihui
Dongguan People's Hospital
Outcome results
None listed