chronic heart failure
Conditions
Interventions
Control group:Electrical stimulation at the lobe of the right ear
Experimental group:transcutaneous vagus nerve stimulation at the tragus of the right ear
Sponsors
Tianjin First Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Stable GDMT for >=4 weeks, symptomatic HF (New York Heart Association Class [NYHA] class iii or class ii if hospitalized for HF within the previous 12 months); 2.Reduced left ventricular ejection fraction (LVEF, =800 pg/mL; 5.6-minute walk distance (6MWD) of 150 to 450 meters, limited by HF symptoms; 6.Absence or sub-maximal dosing of any drug class requires clear documentation of justification based on intolerance or contraindication as a prerequisite for enrollment.
Exclusion criteria
Exclusion criteria: 1. Aged = 8.0% ; 4. Permanent atrial fibrillation, ablation for atrial fibrillation within the prior 3 months; 5. Cardiac resynchronization therapy (CRT) candidates or CRT/CRT-D recipients; 6. Currently implanted with a device for VNS, baroreceptor activation therapy or mechanical ventricular assist.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Left ventricular ejection fraction; | — |
Secondary
| Measure | Time frame |
|---|---|
| American New York Heart Association classification;N-terminal pro-brain natriuretic peptide; | — |
Countries
China
Contacts
Public ContactChen Xin
Department of Cardiology, Tianjin First Central Hospital
Outcome results
None listed