severe acute pancreatitis
Conditions
Interventions
Gold Standard:Gold Standard :The clinical manifestations of infection such as persistent fever were found, and the microorganism culture obtained by fine needle puncture or first invasive drainage (p
Sponsors
Jinling Hospital affiliated to Nanjing University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria for acute pancreatitis in the 2012 Atlanta diagnostic criteria for acute pancreatitis; 2. Aged >=18 years; 3. Patients with AP admitted within 1 week of onset; 4. Necrosis of the pancreas and/or peripancreatic tissue visible on enhanced CT scan; 5. Suspected infected pancreatic necrosis(meets 1 of the following): (1) Body temperature >= 38.5 degree for more than 3 days; (2) Elevated PCT and CRP(PCT> 2ng/ml and CRP>120mg). 6.Informed consent form obtained from the patient or next of kin.
Exclusion criteria
Exclusion criteria: 1. Pregnant pancreatitis; 2. Infected necrosis is diagnosed by gas in the necrotic collection on imaging; 3. Receiving intervention or early surgery due to abdominal compartment syndrome or other reasons before admission; 4. known reason of other infectious disease; 5. Patients with preexisting immune disorders; 6. Discharge or death within 48h of anticipated inclusion in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diagnostic efficacy (including sensitivity, specificity, positive predictive value, and negative predictive value); | — |
Secondary
| Measure | Time frame |
|---|---|
| Cure rates with conservative treatment;Proportion of minimally invasive debridement or open surgery;Days of antibiotic use;local complications rate;bleeding events rate;sepsis rate and septic shock rate;new onset organ failure rate;Worsened organ failure rate;organ failure free days within 28 days of enrollment;C-reactive protein, procalcitonin, IL-6;Length of stay in intensive care ward;hospital length of stay; | — |
Countries
China
Contacts
Public ContactLi Weiqin
Jinling Hospital affiliated to Nanjing University
Outcome results
None listed