Pharmacodynamics
Conditions
Interventions
Experimental group:Esketamine
Control group:Opioids
Sponsors
Department of Anesthesiology, Shanghai Yangpu District Shidong Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1. Patients undergoing elective laparoscopic appendectomy and cholecystectomy; 2. Signed a written informed consent form; 3. Aged from 18 to 50 years, female, no smoking history; 4. American Society of Anesthesiologists(ASA) classification: from I to III; 5. No analgesia/sedation drugs have been used within 24 hours before surgery; 6. No serious endocrine, cardiovascular and respiratory diseases; 7. No mental abnormalities and able to cooperate with the experiment.
Exclusion criteria
Exclusion criteria: 1. People with a history of allergy to anesthetics and contraindications to esketamine, non-steroidal anti-inflammatory drugs, and dexmedetomidine; 2. Patients with mental illness ; 3. Poorly controlled or untreated hypertensive patients (resting arterial pressure exceeding 180/100mmHg); 4. Long-term addiction and dependence on opioids or hypnotic drugs; 5. Patients with severe heart, lung, liver and kidney function; 6. Preoperative respiratory infections and asthma.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the incidence of postoperative nausea and vomiting.; | — |
Secondary
| Measure | Time frame |
|---|---|
| days in hospital; | — |
Countries
China
Contacts
Public ContactChen Haiyan
Department of Anesthesiology, Shanghai Yangpu District Shidong Hospital
Outcome results
None listed