Syphilis
Conditions
Interventions
Group1:treatment with aqueous crystalline penicillin G
Group2:treatment with ceftriaxone
Sponsors
Institute of Dermatology, Chinese Academy of Medical Science
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Randomized enrolment of first-diagnosed neurosyphilis patients (untreated patients referred from other hospitals could also be included); 2. Aged 18 to 75 years; 3. No intravenous or intramuscular injection of antibiotics for treatment of neurosyphilis for the last 3 months. (ACPG, ceftriaxone, procaine penicillin G, etc.); 4. The diagnosis of neurosyphilis should meet the following criteria: (1) History of syphilis infection at any stage; (2) With or without central nervous system manifestations; (3) Laboratory findings: abnormal cerebrospinal fluid (CSF) routine test: elevated white blood cell count: >=5 cells /mL (combined with HIV-infected: > 20 cells /mL) or protein concentration of > 500 mg/L (excluding other diseases that may be affected) and meeting one or more of the following findings reactive CSF VDRL or FTA-ABS test; reactive CSF TPPA or RPR/TRUST tests; 5. Patients voluntarily signed the informed consent.
Exclusion criteria
Exclusion criteria: 1. Allergic to the ACPG/ceftriaxone. 2. Patients were excluded from other central nervous system diseases or conditions that might cause abnormalities in CSF tests. 3. Pregnant and lactating women. 4. Patients had serious adverse reactions during treatment. 5. The standardized treatment is not carried out strictly according to the treatment regimen; or were unable to follow up as required. 6. Patients require termination of treatment, and the efficacy and adverse reactions cannot be evaluated; or request withdrawal from the study. 7. Patients with incomplete clinical data that cannot be counted.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CSF white blood cell count;Serum RPR titer;CSF RPR/VDRL titer;MMSE score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cerebrospinal fluid protein levels; | — |
Countries
China
Contacts
Public ContactWang Qianqiu
Institute of Dermatology, Chinese Academy of Medical Science
Outcome results
None listed