Parkinson's Disease
Conditions
Interventions
control group:Nil
experimental group A:Lycium ruthenicum Murr. was consumed 12g per person per day
experimental group B:Lycium barbarum was consumed 12g per person per day
Sponsors
Ningxia Medical University
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients with primary Parkinson's disease; 2. Hoehn & Yahr stage I-III; 3. Aged from 40 to 80 years; 4. BMI > 18.5; 5. On stable antiparkinsonian medication for at least 4 weeks prior to study enrollment; 6. Volunteered to participate in this study, patients and their family members signed the informed consent.
Exclusion criteria
Exclusion criteria: 1. Diagnosed dementia, major depression, psychosis; 2. Severe diseases of the digestive system, acute or chronic primary diseases of the gastrointestinal tract affecting gastrointestinal function, history of esophageal adhesions, strictures, varicose veins, bile duct and pancreatic diseases, history of gastrointestinal surgery, prior abdominal or anal surgery; 3. Have gastrointestinal and respiratory infections, food poisoning or nosebleeds in need of treatment in the past 2 months; 4. Drugs and substance abuse; 5. Cancer and endocrine diseases such as diabetes and hypothyroidism; 6. Stroke, myocardial infarction, heart failure, known background of severe renal insufficiency, arrhythmia, liver disease, uncontrolled hypertension, and hypokalemia; 7. Had taken health supplements containing excessive intakes of phenolic plant extracts within 3 months prior to intervention; 8. Antibiotics received within 3 months prior to intervention, probiotics, probiotics, and vitamin supplements, and other medical treatments may affect changes in intestinal flora; 9. Have the habit of drinking carbonated drinks, probiotics and prebiotics food; 10. Pregnant and lactating women; 11. Volunteers participating in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| gut microbiota;Blood Metabolomics;Urine metabolomics; | — |
Countries
China
Contacts
Public ContactGao Qinghan
Ningxia Medical University
Outcome results
None listed