Osteoarthritis
Conditions
Interventions
1 group:Single intra-articular injection of HADMSCs
2 group:Rehabilitation therapy daily, five days a week, for up to 8 weeks
Sponsors
Damascus University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Males and females aged 18 to 70 years; 2.Radiological diagnosis of osteoarthritis using the American College of Rheumatology criteria; 3.Radiological grading of Grade II–III osteoarthritis (OA) of the knee as determined by a qualified radiologist using the Kellgren and Lawrence system; 4.Medial or lateral compartment OA; 5.Less than 5 degrees varus or valgus knee deformity as measured by the long mechanical axis of the knee on X-ray; 6.A minimum pain score of equal or greater than 4/10 on a visual analogue scale (VAS).
Exclusion criteria
Exclusion criteria: 1.Previous meniscectomy/significant partial meniscectomy or other knee-related surgery within the last 12 months; 2.Previous intra-articular injectable therapies within the last 6 months; 3.The patients who have meniscus injury of knee joint need surgical repair; 4.The patients who have severe coagulation disorders or cardiopulmonary conditions; 5.The women who are pregnant or nursing; 6.There are electronic implants such as pacemakers in the body; 7.The patients who are infected the HIV, the virus of hepatitis or syphilis or Bleeding disorders; 8.The patients with severe cognitive impairment who cannot follow instructions to complete the treatment; 9.History of cancer; 10.Immunodeficiency patients; 11.History of systemic illness or significant organ impairment/failure (i.e., renal failure); 12.The patients who have congenital or acquired knee malformation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| International Knee Function Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Visual Analogue Scale (VAS); | — |
Countries
Syria
Contacts
Public ContactCheng Hong
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed