cognitive dysfunction induced by nitrous oxide abuse
Conditions
Interventions
treatment group:hyperbaric oxygen therapy
control group:sham-HBOT
Sponsors
Center for Mental Health, West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Both male and female patients with a clear history of exposure to N2O and a history of short-term frequent inhalation, and meeting the diagnostic criteria for substance use disorder in DSM-5; 2.Acute, subacute or chronic onset, with clear symptoms of cognitive decline, such as memory loss, disorientation, attention loss, slow reaction, learning ability, etc.; 3.To participate in the study voluntarily, all subjects should be informed of the study purpose, method, possible discomfort and risk in detail before enrollment, and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1.Patients with organic brain diseases; 2.Abusers of psychoactive substances ; 3.Patients with contraindications for hyperbaric oxygen therapy; 4.Patients with cognitive decline caused by other organic substances or drugs cannot be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Consensus edition of the cognitive function suite test for schizophrenia; | — |
Secondary
| Measure | Time frame |
|---|---|
| Integrated visual and auditory continuous performance test;Stroop color words test;Wisconsin card sorting test;Raven's progressive matrices; | — |
Countries
China
Contacts
Public ContactXu Jiajun
West China Hospital, Sichuan University
Outcome results
None listed