Acute myocardial infarction
Conditions
Interventions
Experimental group1:intracoronary rh-proUK through a self-made side-hole balloon
Experimental group2:intracoronary ticrofiban through a self-made side-hole balloon
Control group:intracoronary saline through a self-made side-hole balloon
Sponsors
Anqing Municipal Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 75 years, male or female; 2. Symptoms < 12 hours, thrombolytic indications, excluding thrombolytic contraindications of patients with ST-segment elevation myocardial infarction; 3. Willing to sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients who have undergone rescue PCI with intravenous thrombolysis; 2. History of intracranial hemorrhage; 3. Ischemic stroke within 3 months; 4. Suspected aortic dissection; 5. Active bleeding or bleeding factors (including menstruation); 6. Severe head and face injury within 3 months; 7. Severe or uncontrolled hypertension (SBP > 180 mmHg or DBP > 110 mmHg); 8. Severe trauma or major surgery or uncompressible vascular bleeding; 9. Patients with malignant tumors; 10. Patients with severe liver and kidney dysfunction; 11. Pregnant women, lactating women or women who may be pregnant; 12. Known allergy or contraindications to study drugs or contrast agents; 13. Patients after coronary artery bypass grafting; 14. Coronary angiography showed culprit vessel blood flow TIMI grade 3, and no obvious signs of thrombosis; 15. Patients participated in the clinical study at the same time.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| corrected TIMI frame count; | — |
Secondary
| Measure | Time frame |
|---|---|
| Interleukin-1ß;Soluble growth-stimulating gene-2;Left ventricular ejection fraction and reperfusion level assessed by cardiac magnetic resonance imaging;Major adverse cardiovascular events during follow-up period; | — |
Countries
China
Contacts
Public ContactQiao Rui
Anqing Municipal Hospital
Outcome results
None listed