liver transplantation
Conditions
Interventions
Experimental group1:0.1g glycyrrhizic acid + 250ml 10% glucose injection, intravenous drip
Experimental group2:465mg Polyene phosphatidylcholine + 250ml 10% glucose injection, intravenous drip
Experimental group3:0.1g glycyrrhizic acid +465mg Polyene phosphatidylcholine + 250ml 10% glucose injection, intravenous drip
Control group:250ml 10% glucose injection, intravenous drip
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
No minimum to 100 Years
Inclusion criteria
Inclusion criteria: 1.The donor and recipient's family members or legal representatives agreed to participate in the experiment and signed the informed consent; 2.Gender and age are not limited; 3.At least one of the following criteria should be included in the criteria of marginal donor: (1) length of stay in intensive care unit > 7 days; (2) Body mass index > 30 kg / m^2; (3) Death due to hypoxia, stroke or other non traumatic causes; (4) Age > 60 years old; (5) The degree of steatosis was more than 40%; (6) Serum sodium > 165 mmol / L; (7) ALT > 105 U / L, AST > 90 U / L, total bilirubin > 51 µ mol/L ; (8) The serum was positive for hepatitis virus; (9) Split liver transplantation, sepsis, meningitis, personal history of extrahepatic malignancy, long-term hypotension .(diastolic blood pressure < 60 mmHg, lasting more than 2 hours, 10 mmHg = 1.33 kPa) or need a large number of vasoactive drugs to maintain blood pressure. If at least one of the liver function indexes in Clause 7 is met, it is the marginal donor liver with abnormal liver function.
Exclusion criteria
Exclusion criteria: 1. The donor had used liver protection drugs for a period of time 24 hours before admission; 2. There was no biochemical examination of liver function in our hospital 24 hours before the donor was enrolled; 3. The donor may not be able to receive at least one intravenous administration within 24 hours.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| poor early graft function, PEGF; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pathological morphology and inflammatory status of liver tissue before transplantation; | — |
Countries
China
Contacts
Public ContactLi Jianbo
West China Hospital, Sichuan University
Outcome results
None listed