orthopedic infection
Conditions
Interventions
Experimental group1:Tazocin and Colimycin
Control group1:Tazocin
Experimental group2:Tazocin and Colimycin and Mepem
Control group2:Tazocin and Mepem
Sponsors
Shanghai Sixth People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. The pathogen was cro; 2. Cro: sputum culture for carbapenem resistant Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii; 3. The age is more than 18 years old (including the boundary value), regardless of gender; 4. Informed consent has been signed by the subject or legal representative.
Exclusion criteria
Exclusion criteria: 1. Patients who are known to be allergic to the study drug or active ingredients; 2. Patients with bloodstream infection; 3. Liver dysfunction (ALT and / or AST) 5 times of the upper limit of normal value, and / or 1.5 times higher than the upper limit of normal value of total bilirubin, or child Pugh score C); 4. Patients with severe renal injury (creatinine clearance rate < 30ml / min); 5. Clinically serious gastrointestinal dysfunction may affect the intake, transportation or absorption of the study drugs, such as uncontrollable nausea or vomiting, history of extensive gastrointestinal resection, recurrent diarrhea without cure, Crohn's disease, ulcerative colitis; 6. Combined use of warfarin, anticonvulsant drugs, statins, cisapride, immunosuppressant drugs, digoxin and ergot drugs 7. Combined use of macrolides, aminoglycosides, tetracyclines, linezolid and other drugs to inhibit the protein synthesis of pathogenic microorganisms; 8. Those who have participated in other clinical trials within 4 weeks before screening; 9. Pregnant women, lactating women and subjects (including male subjects) have pregnancy plans (including sperm donation and egg donation plans) or are unable to take effective contraceptive measures in the next six months; 10. Other circumstances considered unsuitable by the researcher.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| infection control; | — |
Countries
China
Contacts
Public ContactYang Qingcheng
Shanghai Sixth People's Hospital
Outcome results
None listed