Outpatient anesthesia
Conditions
Interventions
Control group:Propofol 2mg/Kg
Experimental group1:Propofol 1mg/Kg+Esketamine 0.2mg/Kg
Experimental group2:Propofol 1mg/Kg+Esketamine 0.3mg/Kg
Experimental group3:Propofol 1mg/Kg+Esketamine 0.4mg/Kg
Sponsors
Department of Anesthesiology, The Second Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 70 years; 2. Patients who clearly have intestinal polyps and need digestive endoscopy; 3. ASA I-III level; 4. 18.5 <= Body mass index (BMI) <= 28; 5. Agree to participate in this study and sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Those who are intolerant to esketamine, ketamine hydrochloride, propofol, rocuronium, opioids and other drugs; 2. Patients who have used anesthetics within 24 hours or have used anesthetics within 15 days; 3. Poorly controlled or untreated hypertension (arterial hypertension-systolic/diastolic blood pressure exceeds 180/100 mmHg at rest); 4. Child liver function grade 3 or above before operation; 5. A history of severe cardiovascular disease (such as myocardial ischemia, heart failure, and arrhythmia, etc.); 6. Angina pectoris (unstable angina) caused by insufficient blood supply to the coronary blood vessels, or myocardial infarction occurred within the last 6 months patient; 7. Patients with craniocerebral injury, possible intracranial hypertension, cerebral aneurysm, cerebrovascular accident, and central nervous system disease; 8. Patients with hyperthyroidism; 9. Pregnant or lactating women; 10. Increased intraocular pressure (glaucoma) or puncture eye injury; 11. A history of drug and/or alcohol abuse within 3 months; 12. Patients with asthma; 13. Patients with mental system diseases (schizophrenia, mania, bipolar disorder, confusion, etc.), drug history and cognitive dysfunction; 14. Those who have participated in other drug trials three months before being selected; 15. The attending doctor or researcher believes that there are other situations that are not suitable for participating in this research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood pressure;Respiratory rate;Heart rate;Oxygen saturation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Propofol total dosage;Saliva volume;Time of resuscitation;Score of resuscitation; | — |
Countries
China
Contacts
Public ContactDan Ling
Department of Anesthesiology, the Second Affiliated Hospital of Chongqing Medical University
Outcome results
None listed