Comparison of curative effect of modified endoscopic retrograde appendicitis in children with acute uncomplicated appendicitis

Comparison of modified endoscopic retrograde appendicitis with laparoscopic appendectomy and antibiotics alone in the treatment of acute uncomplicated appendicitis in children

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100047014

Enrollment

Unknown

Registered

2021-06-07

Start date

2021-06-01

Completion date

Unknown

Last updated

2022-01-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

appendicitis

Interventions

Group A:Endoscopic retrograde appendicitis therapy

Group A:antibiotic therapy

Group A:(Laparoscopic appendectomy

Eligibility

Sex/Gender

All

Age

1 Years to 16 Years

Inclusion criteria

Inclusion criteria: 1.1-16 years old children with acute appendicitis (the diagnosis of acute appendicitis is based on clinical symptoms (abdominal pain, fever, vomiting), infection indicators (blood routine, CRP, PCT) and computed tomography (CT) and/or ultrasound (US) examinations : Manifested as dilation of the appendix lumen (outer diameter>6mm); thickening of the appendix tube wall>3mm); 2. After the doctor in charge introduces the three treatment methods in detail, the patient and (or) guardian sign a consent form, and choose any of the mERAT treatment, antibiotic conservative treatment, and laparoscopic appendectomy treatment.

Exclusion criteria

Exclusion criteria: 1. Children with appendiceal perforation, diffuse peritonitis or periappendiceal abscess; 2. Abdominal X-ray films indicating the causes of free air in abdominal cavity and acute abdomen such as urinary and gynecological diseases; 3. Patients with severe cardiopulmonary diseases who cannot tolerate endoscopy; 4. Suspected severe patients with shock, gastrointestinal perforation, intestinal necrosis, complete intestinal obstruction, etc; 5. Patients with gastrointestinal bleeding, whose blood pressure is not stable; 6. Patients with bleeding tendency and hemoglobin lower than 50g / L; 7. Children allergic to contrast medium; 8. Combined with other diseases requiring hospitalization.

Design outcomes

Primary

Measure	Time frame
treatment success rate;	—

Secondary

Measure	Time frame
the duration of the relief of pain;length of hospitalization;complication;Operation time;Postoperative antibiotic use time;Conversion to open surgery;Appendectomy rate and recurrence rate during the follow-up period;	—

Countries

China

Contacts

Public ContactJiang Xun

Tangdu Hospital, Air Force Medical University

863756276@qq.com+86 029-84777747

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026