Alzheimer's disease
Conditions
Interventions
Alzheimer's disease Group-mild:No intervention
Alzheimer's disease-moderate:No intervention
Sponsors
China-Japan Friendship Hospital
Eligibility
Sex/Gender
All
Age
40 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Alzheimers disease entry criteria: meet the National Institute on Aging–Alzheimers Association (NIA-AA): (1) The chief complaint of memory loss, which was confirmed by an insider; (2) Based on clinical examination, the diagnosis of dementia can be made and verified by cognitive scale test (20 items ADL>26 points; CDI>1 point); (3) Unconscious disorder; (4) All cases undergo MRI examination and related laboratory examinations, except for other diseases that can cause progressive impairment of memory and cognitive function; (5) Amyloid/p-Tau increased in PET tracing or Aß1-42 in cerebrospinal fluid increased with/or P-Tau increased. 2. Entry criteria for mild cognitive impairment: (1) The main complaint was memory loss, which was confirmed by an insider; (2) Objective inspection revealed mild cognitive impairment that was not commensurate with age and education level; (3) The overall cognitive function is normal, the basic ability of daily life is normal, and complicated daily or social functions may be slightly impaired; (4) No dementia (CDR0.5 points, 20 items ADL 27/30 points and normal neuropsychological evaluation; (2) Clinical Dementia Score (CDR) score = 0; (3) No history of neurological or mental illness; (4) No memory complaints or cognitive deficits.
Exclusion criteria
Exclusion criteria: 1. Sudden onset; 2. Early general situational memory impairment; 3. Cognitive disorders caused by depression, cerebrovascular, moderate, inflammation or metabolic disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood early biomarkers for Alzheimer's disease;skull PET/CT(MR);Assessment of cognitive function; | — |
Countries
China
Contacts
Public ContactPeng Dantao
China-Japan Friendship Hospital
Outcome results
None listed