thoracolunbar spinal operation
Conditions
Interventions
Dexmedetomidine intravenous pump administration group:Intravenous infusion
Dexmedetomidine intranasal administration group:Intranasal administration
Dexmedetomidine intratracheal administration group:Intratracheal administration
Sponsors
The Third Affiliated Hospital of Anhui Medical University (The First People's Hospital of Hefei)
Eligibility
Sex/Gender
All
Age
61 Years to 90 Years
Inclusion criteria
Inclusion criteria: Elderly patients to be scheduled for thoracolunbar spinal operation under general anesthesia.
Exclusion criteria
Exclusion criteria: 1. Body mass index >= 30 kg/m2, basic heart rate <50 beats/min, abnormal liver and kidney function, pregnancy, abnormal hearing, mental retardation, long-term use of opioids or sedatives, and contraindications to the drugs used in this study; 2. History of difficult airway or maxillofacial surgery, chronic respiratory disease, respiratory tract infection, history of smoking, tracheal tube indwelling more than 4 hours or more than 1 hour after the operation without extubation, and transfer to the ICU with a tube after the operation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative sleep quality;Levels of Inflammatory cytokines;The incidence of POST and PONV; | — |
Countries
China
Contacts
Public ContactYu Junma
The Third Affiliated Hospital of Anhui Medical University (The First People's Hospital of Hefei)
Outcome results
None listed