Pain after lung resection
Conditions
Interventions
Group L:0.2µg/kg/h dexmedetomidine was continuously infused during the operation, and 0.2µg/kg dexmedetomidine was given 10min minutes before the end of the operation.
Group H:0.4µg/kg/h dexmedetomidine was continuously infused during the operation, and 0.2µg/kg dexmedetomidine was given 10min minutes before the end of the operation
Group C:Intraoperative continuous infusion of normal saline
Sponsors
Sun Yat-Sen University Cancer Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. ASA physical status I or II; 2. Patients aged 19 to 75 years.
Exclusion criteria
Exclusion criteria: 1. A history of anaesthetic allergy; 2. Patients with severe liver, kidney, hematopoiesis and other diseases; 3. BMI>30kg/m2; 4. Pregnant women; 5. Long-term use of opioids (> 1 year); 6. Patients expecting difficult airway; 7. patients with daily bradycardia (HR<50 beats/min; 8. Arrhythmia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Resting and exercise NRS scores;Mechanical pain threshold in the peri-operative area and right forearm (the vertical distance of palmar elbow print is 3, 6, 9cm);Patient satisfaction with postoperative pain control; | — |
Secondary
| Measure | Time frame |
|---|---|
| The amount of vasoactive drugs and the amount of fluid replacement;The dosage of opioids during operation;MAC and anesthesia depth of sevoflurane during operation;Extubation time;Hospitalization time;hospitalization time in intensive care unit;The time of the first use of analgesics after operation;Postoperative opioid dosage and use time;Additional use of painkillers (e.g. non-steroidal drugs, etc.);Side effects related to anesthesia: such as postoperative nausea and vomiting, irritability, delirium, itching, urine retention, constipation, etc.; | — |
Countries
China
Contacts
Public ContactCao Longhui
Sun Yat-Sen University Cancer Center
Outcome results
None listed