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Study on the brain analgesia mechanism of Tuina in the treatment of acute pain after total knee arthroplasty based on resting state BOLD-fMRI

Study on the brain analgesia mechanism of Tuina in the treatment of acute pain after total knee arthroplasty based on resting state BOLD-fMRI

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100046972
Enrollment
Unknown
Registered
2021-06-06
Start date
2021-06-07
Completion date
Unknown
Last updated
2022-01-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Pain after Total Knee Arthroplasty

Interventions

Tuina group:???
Control group:No

Sponsors

Guanghua Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
50 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Aged 50 to 65 years; 2. Diagnosed as knee osteoarthritis, hospitalized elective cases of unilateral total knee replacement under general anesthesia, without surgical contraindications, agree to participate in this experiment; 3. The American Association of Anesthesiologists (ASA) is classified as I or II; 4. All affected limbs are left knee; 5. All right-handed; 6. Agree and sign the informed consent form.

Exclusion criteria

Exclusion criteria: 1. It has been diagnosed with deep vein thrombosis or lower extremity swelling before the operation; 2. Severe arrhythmia, heart failure, chronic obstructive pulmonary disease, epilepsy, mental illness; 3. Those with brain injury found after baseline fMRI; 4. There are obvious mood swings within 24 hours before fMRI scan; 5. Drink alcohol, coffee, strong tea, etc. within 24 hours before fMRI scan; 6. During fMRI scan, it is found that the skulls on both sides have serious structure or definite damage; 7. If an acute or serious event or adverse event occurs during the study period, you should not continue to participate in the experiment; 8. Patients who receive other related treatments by themselves during the experiment; 9. Poor compliance, unwilling to participate in the experiment after many explanations, or unable to complete the experiment cycle.

Design outcomes

Primary

MeasureTime frame
Regional Homo-geneity;Amplitude of Low Frequency Fluctuation;Functional Connectivity;

Secondary

MeasureTime frame
Pressure Pain Thresholds;Numerical rating scale;Hamilton Depression Scale;Pain Catastrophizing Scale;

Countries

China

Contacts

Public ContactXiao Lianbo

Guanghua Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine

xiao_lianbo@163.com+86 13849429347

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026