Acute Pain after Total Knee Arthroplasty
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. Aged 50 to 65 years; 2. Diagnosed as knee osteoarthritis, hospitalized elective cases of unilateral total knee replacement under general anesthesia, without surgical contraindications, agree to participate in this experiment; 3. The American Association of Anesthesiologists (ASA) is classified as I or II; 4. All affected limbs are left knee; 5. All right-handed; 6. Agree and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. It has been diagnosed with deep vein thrombosis or lower extremity swelling before the operation; 2. Severe arrhythmia, heart failure, chronic obstructive pulmonary disease, epilepsy, mental illness; 3. Those with brain injury found after baseline fMRI; 4. There are obvious mood swings within 24 hours before fMRI scan; 5. Drink alcohol, coffee, strong tea, etc. within 24 hours before fMRI scan; 6. During fMRI scan, it is found that the skulls on both sides have serious structure or definite damage; 7. If an acute or serious event or adverse event occurs during the study period, you should not continue to participate in the experiment; 8. Patients who receive other related treatments by themselves during the experiment; 9. Poor compliance, unwilling to participate in the experiment after many explanations, or unable to complete the experiment cycle.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Regional Homo-geneity;Amplitude of Low Frequency Fluctuation;Functional Connectivity; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pressure Pain Thresholds;Numerical rating scale;Hamilton Depression Scale;Pain Catastrophizing Scale; | — |
Countries
China
Contacts
Guanghua Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine