Deep II degree of burns and scalds
Conditions
Interventions
experimental group:Collagenase ointment
Sponsors
Shanghai Changhai Hospital Burn Department
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 65 years, gender is not limited, hospitalized 48-96 hours after injury, clinical diagnosis of deep second degree burns; (The basis for the diagnosis of burns and scald depth: the fourth-degree five-point method, for the estimation of the wound area using China 9 Division method and palm method; diagnosis and judgment are jointly completed by 2 attending physicians or above in each center.) 2. The total area of burns and scalds <= 30% TBSA (total area of the body surface), the test area is 10-100cm2, located on the limbs or trunk, the wound is clean and free of infection; choose an isolated wound as the test area as far as possible; 3. The subjects are fully informed and voluntarily sign the informed consent form, and can complete the trial and follow-up in accordance with the requirements of the protocol.
Exclusion criteria
Exclusion criteria: 1. Those who are contraindicated or allergic to study drugs (ie, collagenase ointment and silver sulfadiazine ointment) or their ingredients; 2. Those who have clear and severe heart, brain, liver, kidney and other organ dysfunction, or related skin diseases that may cause the wound to fail to heal normally; 3. Immune dysfunction, HIV-infected patients, or patients who have been treated with radiation, hormones (systemic medication), chemotherapy, growth factors, and immunosuppressive drugs within 1 month; 4. Burns from special causes such as chemical, electrical, and radiation; 5. Critically ill patients with multiple injuries and compound injuries such as inhalation injury and trauma; 6. Those with unstable blood glucose control, such as fasting blood glucose >= 8.0mmol/L or postprandial blood glucose >= 12.0mmol/L; 7. Those who have mental illness and have no insight and cannot express accurately; 8. The assessment of pregnant women or other researchers is not suitable for participating in the research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean wound healing time; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mean removal time of necrotic tissue from wound surface;Total wound healing rate;Evaluation of wound inflammatory response;Wound pain assessment;Evaluation of scar hyperplasia; | — |
Countries
China
Contacts
Public ContactXia Zhaofan, Ji Shizhao
Changhai Hospital
Outcome results
None listed