Effects of continuous intraoperative intravenous ketamine infusion on postoperative pain in patients with lobectomy: a prospective randomized double-blind trial

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100046970

Enrollment

Unknown

Registered

2021-06-06

Start date

2021-07-01

Completion date

Unknown

Last updated

2022-03-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

lung cancer

Interventions

Group 1:Ketamine was continuously infused with 2µg/kg/min during the operation

Group 2:Ketamine was continuously infused with 5µg/kg/min during the operation

Group3:An equal volume of normal saline was pumped intraoperatively

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. ASA classification I~II; 2. Aged 19 to 75 years.

Exclusion criteria

Exclusion criteria: 1. Allergic to the drugs involved in the research program; 2. Patients with severe liver, kidney, hematopoietic system and other diseases; 3. BMI > 30kg/m2; 4. Pregnant women; 5. Long-term use of opioids (>1 year); 6. Anticipating patients with difficult airways; 7. Patients with daily bradycardia (HR<50 beats/min); 8. History of arrhythmia.

Design outcomes

Primary

Measure	Time frame
Mechanical pain threshold;Digital Pain Rating Scale(NRS score);	—

Countries

China

Contacts

Public ContactTan Hongying

Cancer Prevention Center, Sun Yat-Sen University

tanhongy@sysucc.org.cn+86 13556063870

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026