Chronic constipation
Conditions
Interventions
Placebo group:Placebo
Bifidobacterium bifidum CCFM16 group:2 billion Bifidobacterium bifidum CCFM16
Sponsors
The Peoples' Hospital of Tinghu District of Yancheng City
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnositc criteria of Rome IV; 2. Aged 18 to 80 years; 3. Have not taken with probiotics (such as lactic acid bacteria, bifidobacteria, etc.) yogurt, beverages and etc. In the past two months; Adhere to the requirements of taking probiotic productions for 2 months; Cooperate with the survey And the collection of blood samples, feces and other biological samples; 4. Volunteers who sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Constipation due to other diseases, functional defecation disorders and medications, such as: Parkinson's syndrome, anterior rectal distention pelvic floor spasm, megacolon, hypothyroidism and patients on long-term pain medication. 2. Those who cannot comply with observation due to alcoholism, substance abuse or psychiatric factors. 3. Patients with chronic laxative abuse. 4. Patients who are estimated to have poor compliance and poor follow-up possibilities 5. Recent (4 weeks) consumption of probiotic products or long-term consumption of yogurt or probiotic drinks. 6. Recent (4 weeks) or long-term use of antibiotics. 7. Allergy or intolerance to the ingredients of the tested probiotic product. 8. Pregnant or breastfeeding women, or women who plan to become pregnant or breastfeed during the study period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fecal flora;SCFAs in feces;Serological indicators;Blood routine test;Routine uninalysis;High sensitive C reactive protein;Blood lipid;Liver function; | — |
Secondary
| Measure | Time frame |
|---|---|
| Height;Weight; | — |
Countries
China
Contacts
Public ContactWang Gang
Jiangnan University
Outcome results
None listed