spinocerebellar ataxia
Conditions
Interventions
Sponsors
Xiangya Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Diagnosis as spinocerebellar ataxia type 1 or 2 or 3 by genetic testing; 2. Age between 18 to 65 years, man or woman; 3. Scale of gait from 2 to 6 in Scale for the Assessment and Rating of Ataxia (SARA); 4. Patients with no drug therapy or stable drug therapy within 1 month before screening; 5. Subjects who never receive rTMS or stem cell therapy within 3 months before screening; 6. Not paticipating in other clinical trials during study; 7. Consent informed before study.
Exclusion criteria
Exclusion criteria: Exclusion criteria for rTMS therapy: 1. Patients with other neurological and psychiatric diseases; 2. Patients with diseases that disturb scale grading, e.g. fracture failure; 3. Pregnant or breast-feeding women; 4. Patients with intracranial or intracardiac implants, e.g. deep brain stimulator, cardiac pacemaker. Exclusion criteria for MRI examination: 1. Patients with other chronic somatic diseases, e.g. hypertension, diabetes; 2. Patients with intracranial or intracardiac implants, e.g. deep brain stimulator, cardiac pacemaker; 3. Patients with helicobia; 4. Patients take neurological and psychiatric drugs, e.g. sedative-hypnotics, antiepileptic drugs, antipsychotic drugs, or narcotics.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Scale for the Assessment and Rating of Ataxia;International Cooperative Ataxia Rating Scale;magnetic resonance spectroscopy;resting-state functional magnetic resonance imaging; | — |
Secondary
| Measure | Time frame |
|---|---|
| Ten Miles Walk Test;9-Hole Peg Test;PATA test; | — |
Countries
China
Contacts
Public ContactJiang Hong
Xiangya Hospital
Outcome results
None listed