The effects of bicarbonated versus acetated Ringer's solutions on acid-base state and renal injury following orthotopic liver transplantation

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100046889

Enrollment

Unknown

Registered

2021-05-29

Start date

2021-06-15

Completion date

Unknown

Last updated

2022-01-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Group 1:Ringer's Acetate

Group 2:Sodium Bicarbonate Ringer's Solution

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Recipients undergoing liver transplant surgery; 2. Aged >= 18 years.

Exclusion criteria

Exclusion criteria: 1. Patients undergoing multiple organ transplant operations at the same time; 2. Patients who already have chronic kidney disease (CKD) stage 3 or above (definition: GFR<60ml/min/1.73m^2 for more than 3 months); 3. Patients who have had acute kidney injury before surgery (definition: SCr increased by more than 1.5 times compared with baseline or SCr increased by more than 26.5umol/L (0.3mg/dL) within 48 hours or urine output < 0.5ml/( kg*h) lasting more than 6 hours, the baseline is defined as the SCr level obtained during physical examination within half a year. If it is not available, it is set as the upper limit of normal: 90µmol/L (female)/110µmol/L (male)); 4. Pregnant patients.

Design outcomes

Primary

Measure	Time frame
The difference of SBE between before operation and immediate post operation (?SBE = SBEpost - SBEpre);	—

Secondary

Measure	Time frame
The amount of bicarbonated/acetated Ringer’s solution used during and within the first 2 twenty-four hours post operation;Sodium bicarbonated used to maintain acid-base state during and within the first 2 twenty-four hours post operation;Serum acetic acid concentration;Incidence of acute kidney injury within 48 hours after operation;SCr, Cystatin C level;Serum NGAL levels;Blood gas analysis (pH, SBE, HCO3-, Lac, Cl-);Effective SID (eSID=[Na+]+[K+]+[Ca2+]+[Mg2+]-[Cl-]-[Lac-]);Rate of new renal replacement therapy started 14 days after surgery;No renal replacement therapy days after 14 days;Incidence of new organ failure within 14 days after operation;ICU free and alive days within 14 days after operation;Mortality within 14 days after operation;	—

Measure

Time frame

The amount of bicarbonated/acetated Ringer’s solution used during and within the first 2 twenty-four hours post operation;Sodium bicarbonated used to maintain acid-base state during and within the first 2 twenty-four hours post operation;Serum acetic acid concentration;Incidence of acute kidney injury within 48 hours after operation;SCr, Cystatin C level;Serum NGAL levels;Blood gas analysis (pH, SBE, HCO3-, Lac, Cl-);Effective SID (eSID=[Na+]+[K+]+[Ca2+]+[Mg2+]-[Cl-]-[Lac-]);Rate of new renal replacement therapy started 14 days after surgery;No renal replacement therapy days after 14 days;Incidence of new organ failure within 14 days after operation;ICU free and alive days within 14 days after operation;Mortality within 14 days after operation;

—

Countries

China

Contacts

Public ContactLi Weiqin

Jinling Hospital Affiliated to Nanjing University School of Medicine

ctgchina@medbit.cn+86 13951839654

Outcome results