A comparative study of Ciprofol and Propofol in induction of general anesthesia during total hip replacement surgery in the elderly

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100046886

Enrollment

Unknown

Registered

2021-05-29

Start date

2021-05-31

Completion date

Unknown

Last updated

2022-01-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Group 1:Use Propofol 1.5 mg/kg for induction

Group 2:Use Ciprofol 0.2 mg/kg for induction

Group 3:Use Ciprofol 0.3mg/kg for induction

Eligibility

Sex/Gender

All

Age

65 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Elective total hip replacement surgery requiring tracheal intubation; 2. Aged 65-75 years, no gender limit; 3. BMI 18-30kg/m^2; 4. ASA classification II or III; 5. Vital signs: respiratory frequency >=10 and =95% when breathing air; systolic blood pressure (SBP) >=90mmHg and =60mmHg and =55 and <=100 beats/min.

Exclusion criteria

Exclusion criteria: 1. Those who have general anesthesia contraindications or have a history of anesthesia accidents in the past; 2. Known or suspected allergies or contraindications to propofol injection, cyclopofol injection excipients, benzodiazepines, opioids, muscle relaxants, etc.; 3. Patients with acute upper respiratory tract infection, asthma attack or acute severe throat disease; 4. Have a history of gastrointestinal diseases: gastrointestinal retention, active bleeding, possible reflux and aspiration, etc.; 5. Combined with history of brain loss, intracranial hypertension, stroke, cerebrovascular accident, etc.; 6. Respiratory insufficiency, obstructive lung disease, difficult airway, or difficulty in tracheal intubation (modified Markov score is III or IV); 7. Uncontrolled hypertension, hypotension and diabetes; 8. Severe arrhythmia, heart failure, unstable angina, myocardial infarction, etc.; 9. Severe liver dysfunction or severe renal insufficiency; 10. History of alcohol abuse or drug dependence; 11. Abuse or long-term use of narcotic, sedative, and analgesic drugs; 12. Those who have a history of mental illness; 13. Those who have participated in any drug clinical trial within the previous month; 14. The investigator believes that there are any other patients who are not suitable to participate in this trial.

Design outcomes

Primary

Measure	Time frame
The onset time of Ciprofol or Propofol;	—

Countries

China

Contacts

Public ContactLong Yan

Changzhou Hospital of Traditional Chinese Medicine

2313987158@qq.com+86 18168808291

Outcome results