None listed
Conditions
Interventions
Group 1:Remiazolam benzenesulfonate 5mg + sufentanil 0.05~0.1ug/kg
Group 2:Remiazolam benzenesulfonate 0.15mg / kg / kg + sufentanil 0.05~0.1ug/kg
Group 3:Propofol 1mg hand kg + sufentanil 0.05ug/kg
Sponsors
Affiliated Hospital of Guizhou Medical University
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged > 65 years, no gender limit; 2. Patients receiving routine gastroscopy diagnosis and treatment; 3. The ASA score is I - III; 4. 18 kg/ m^2 < BMI < 30kg/m^2; 5. Patients clearly understand and voluntarily participate in the study, and sign an informed consent form by themselves.
Exclusion criteria
Exclusion criteria: 1. Patients who intend to undergo tracheal intubation (including laryngeal mask); 2. Acute heart failure, unstable angina, myocardial infarction occurred within 6 months before screening, resting ECG heart rate = 450ms, female >= 470ms; 3. Patients suffering from severe respiratory disease (obstructive sleep apnea syndrome, acute respiratory infection, acute exacerbation of chronic obstructive pulmonary disease, uncontrolled asthma, etc.); 4. Patients suffering from mental system diseases (schizophrenia, mania, bipolar disorder, confusion, etc.) and long-term use of psychiatric drugs and cognitive dysfunction; 5. Patients who are judged to be difficult to manage the respiratory tract (modified Markov score is grade IV); 6. Anemia or thrombocytopenia: Hb = 160 mmHg or = 100 mmHg during the screening period); 9. Those who are allergic or contraindicated to benzodiazepines, opioids, propofol and other drugs and their drug components; 10. Participated in other drug clinical trials as subjects in the past 3 months; 11. The investigator believes that it is not appropriate to participate in this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sedation success rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sedation induction time;Sedation and awakening time;Discharge time;Incidence of sedative hypotension;Incidence of respiratory depression during sedation;Satisfaction scores of anesthesiologists, endoscopists and patients;Incidence of sedative hypotension requiring treatment; | — |
Countries
China
Contacts
Public ContactZou Xiaohua
Affiliated Hospital of Guizhou Medical University
Outcome results
None listed