Chronic hepatitis B
Conditions
Interventions
Intervention group:peginterferon a-2b
Sponsors
The First People's Hospital of Yunnan Province
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-60 years; 2. Positive HBsAg more than half a year with negative HBeAg and normal ALT, qHBsAg>3000IU/ml; 3. No antiviral treatment within six months before being selected; 4. For patients of childbearing age, agree to choose appropriate contraceptive measures (including at least one barrier contraceptive method) throughout the trial period; 5. Volunteer to join this study and sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Those who have used hepatoprotective drugs within 1 month before being selected; 2. Serum anti-HIV positive; 3. Liver diseases caused by other causes 4. Patients who have progressed to liver cirrhosis or hepatocellular carcinoma; 5. Accompanied by serious or uncontrollable underlying diseases: such as infections, cardiovascular and cerebrovascular accidents, diabetes, epilepsy, rheumatoid arthritis, malignant tumors, etc.; 6. Pregnant and lactating women; 7. History of alcohol or drug abuse; 8. Participating in other hepatitis drug trials within 3 months or currently; 9. Subjects who are not suitable to participate in the research according to the researcher's judgment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The ratio of qHBsAg<1500IU/ml; | — |
Secondary
| Measure | Time frame |
|---|---|
| Clearance of HBsAg; | — |
Countries
China
Contacts
Public ContactGeng Jiawei
The First People's Hospital of Yunnan Province
Outcome results
None listed