heart failure
Conditions
Sponsors
The First Affiliated Hospital of Harbin Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients were hospitalized with the primary diagnosis of acute decompensation of chronic heart failure and had consistent signs and symptoms; 2. NYHA class III/IV; 3. Ejection fraction =400 pg per milliliter or an N-terminal pro-BNP (NT-proBNP) level >= 1600 pg per milliliter, 5. Systolic blood pressure at least 100 mmHg; 6. Estimated glomerular filtration rate (eGFR) >= 30 mL/min per 1.73 m2 (calculated by the Modification of Diet in Renal Disease formula); 7. Potassium concentration = 18 years.
Exclusion criteria
Exclusion criteria: 1. A history of angioedema or other unacceptable side effects of ACEI or ARB; 2. An allergy history of any ingredient of sacubitril/valsartan; 3. Occurrence of acute myocardial infarction in the previous month; 4. Being in perinatal period; 5. Presence of diseases that may seriously affect drug metabolism; 6. The patient's life expectancy less than 6 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| death from cardiovascular causes; | — |
Secondary
| Measure | Time frame |
|---|---|
| the readmission for HF;NYHA grade;6-minute walk distance; | — |
Countries
China
Contacts
Public ContactLi Weimin
Department of Cardiology, The First Affiliated Hospital of Harbin Medical University
Outcome results
None listed