Stroke of large artery atherosclerosis with diabetes mellitus type 2
Conditions
Interventions
DPP-4 inhibitors group:Nil
Non-DPP-4 inhibitor hypoglycemic drugs:Nil
Sponsors
Shanghai Tenth People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged >= 18 years; 2. Diagnosed as acute ischemic stroke (TOAST classification is large artery atherosclerosis) according to the "Chinese guidelines for diagnosis and treatment of acute ischemic stroke 2018" within 3 days, and undergoes standardized treatment; 3. Diagnose as type 2 diabetes according to the 2020 edition of "Guidelines for Prevention and Treatment of Type 2 Diabetes in China"; 4. Sign the informed consent form voluntarily; 5. Cooperate to complete the clinical follow-up.
Exclusion criteria
Exclusion criteria: 1. History of hemorrhagic stroke; 2. History of severe central nervous system degenerative diseases; 3. History of severe liver and kidney damage, thyroid disease; 4. History of malignant tumors; 5. History of hormone therapy within 6 months; 6. History of autoimmune diseases; 7. History of surgery or trauma within 2 weeks; 8. Participating in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Head MRI;Fasting blood glucose;Modified Rankin scale score;LDL-C;ox-LDL-C;Relapse-Free Survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| Glycated hemoglobin;NIHSS score;Carotid artery plaque;Blood pressure;Homocysteine;Total cholesterol;Triglycerides;HDL-C;Mini-Mental State Examination Score;Montreal Cognitive Assessment Score;Body Mass Index; | — |
Countries
China
Contacts
Public ContactTan Yan
Department of Neurology, Shanghai Tenth People's Hospital, Tongji University
Outcome results
None listed