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Efficacy and safety of heparin in peripherally inserted central catheter (PICC) in premature infants

Effect of adding heparin to parenteral nutrition on catheter occlusion of peripherally inserted central catheter in preterm neonates: A non-inferiority, randomized controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100046771
Enrollment
Unknown
Registered
2021-05-28
Start date
2021-06-01
Completion date
Unknown
Last updated
2024-09-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Preterm neonates

Interventions

Heparin group:When PICC is used, heparin is added in PN for continuous infusion
No-heparin group:Heparin is not added

Sponsors

West China Second University Hospital of Sichuan University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1.Neonates of gestational age < 32 weeks; 2.Requiring PICC to receive PN, as decided by the neonatology clinical team.

Exclusion criteria

Exclusion criteria: 1.Neonates of gestational age =32 weeks; 2. Intraventricular hemorrhage of grade 3 or 4; 3. bleeding tendencies or disseminated intravascular coagulation; 4. Severe thrombocytopenia; 5. Arrhythmia or severe liver disease,congenital malformation.

Design outcomes

Primary

MeasureTime frame
Ratio of blocked area of thrombosis at each catheter tip;—

Secondary

MeasureTime frame
Duration of catheter patency;Incidence of catheter-related complications;Incidence of heparin-related side effects;—

Countries

China

Contacts

Public ContactShi Jing

West China Second University Hospital of Sichuan University

shijing@scu.edu.cn+86 139 8183 2975

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026